General Information

    • DRAMP ID

    • DRAMP01788

    • Peptide Name

    • Temporin-HN2 (Frogs, amphibians, animals)

    • Source

    • Odorrana hainanensis (Hainan odorous frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • NILNTIINLAKKIL

    • Sequence Length

    • 14

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=4.8 µM), Staphylococcus carnosus KHS (MIC=19 µM), Bacillus licheniformis X39 (MIC=19 µM),Rhodococcus rhodochrous X15 (MIC=2.4 µM);
      • Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=37.5 µM).
      • Fungi: Slime mould 090223 (MIC=9.5 µM) and Candida albicans ATCC2002 (MIC=9.5 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01788 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01788.

Physicochemical Information

    • Formula

    • C73H133N19O19

    • Absent Amino Acids

    • CDEFGHMPQRSVWY

    • Common Amino Acids

    • I

    • Mass

    • 1580.97

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +2

    • Boman Index

    • 2.66

    • Hydrophobicity

    • 0.871

    • Aliphatic Index

    • 202.14

    • Half Life

      • Mammalian:1.4 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01788

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis.

    • Reference

    • Peptides. 2012 Jun;35(2):285-290.

    • Author

    • Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J.