• DRAMP ID

    • DRAMP01790
    • Peptide Name

    • Temporin-1Vb (Temporin 1Vb; Frogs, amphibians, animals)
    • Source

    • Rana virgatipes (Ranidae) (Aquarana)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • FLSIIAKVLGSLF
    • Sequence Length

    • 13
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • [Ref.15996769]Gram-positive bacteria: Staphylococcus aureus NCTC8325 (MIC=5 µM), S. aureus (MRSA) T7/20 (MIC=10 µM), S. epidermidis RP62A (MIC=5 µM), Enterococcus faecalis ATCC 29212 (MIC=20 µM), Streptococcus group B HNTCC 80130 (MIC=20 µM).
    • Hemolytic Activity

      • [Ref:15996769]LD50=30 μM against washed human erythrocytes
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01790 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01790.
    • Formula

    • C70H114N14O16
    • Absent Amino Acids

    • CDEHMNPQRTWY
    • Common Amino Acids

    • L
    • Mass

    • 1407.76
    • PI

    • 8.75
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +1
    • Boman Index

    • 25
    • Hydrophobicity

    • 2.008
    • Aliphatic Index

    • 180
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP01790

    • Function

    • It also has weak hemolytic activty.
  • ·Literature 1
    • Title

    • Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana).
    • Reference

    • Regul Pept. 2005 Nov;131(1-3):38-45.
    • Author

    • Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR.