General Information

    • DRAMP ID

    • DRAMP01791

    • Peptide Name

    • Temporin-1Vc (Temporin 1Vc; Frogs, amphibians, animals)

    • Source

    • Rana virgatipes (Ranidae) (Aquarana)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLPLVTMLLGKLF

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.15996769]Gram-positive bacteria: Staphylococcus aureus NCTC8325 (MIC=5 µM), S. aureus (MRSA) T7/20 (MIC=10 µM), S. epidermidis RP62A (MIC=10 µM), Enterococcus faecalis ATCC 29212 (MIC=40 µM), Streptococcus group B HNTCC 80130 (MIC=40 µM);
      • Gram-negative bacteria: Klebsiella pneumoniae KK3 9904 (MIC=80 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=160 µM), Enterobacter cloacae HNTCC 53001 (MIC=40 µM).

    • Hemolytic Activity

      • [Ref:15996769]LD50=30 μM against washed human erythrocytes

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01791 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01791.

Physicochemical Information

    • Formula

    • C75H122N14O15S

    • Absent Amino Acids

    • ACDEHINQRSWY

    • Common Amino Acids

    • L

    • Mass

    • 1491.94

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +1

    • Boman Index

    • 29.77

    • Hydrophobicity

    • 1.854

    • Aliphatic Index

    • 172.31

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP01791

Comments Information

    • Function

    • It also has weak hemolytic activty.

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana).

    • Reference

    • Regul Pept. 2005 Nov;131(1-3):38-45.

    • Author

    • Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR.