• DRAMP ID

    • DRAMP01811
    • Peptide Name

    • Temporin-Ra (Frogs, amphibians, animals)
    • Source

    • Rana ridibunda (marsh frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • FLKPLFNAALKLLP
    • Sequence Length

    • 14
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-negative bacteria: Escherichia coli (MIC=24.2 µg/ml), Klebsiella pneumoniae PTCC 1388 (MIC=31.2 µg/ml);
      • Gram-positive bacteria: Streptococcus dysgalactiae PTCC 1074 (MIC=33.2 µg/ml), Streptococcus agalactiae PTCC 1365 (MIC=24.7 µg/ml) and Staphylococcus aureus PTCC 1431 (MIC=35.2 µg/ml).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01811 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C80H129N17O16
    • Absent Amino Acids

    • CDEGHIMQRSTVWY
    • Common Amino Acids

    • L
    • Mass

    • 1585.01
    • PI

    • 10
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +2
    • Boman Index

    • 16.44
    • Hydrophobicity

    • 0.979
    • Aliphatic Index

    • 153.57
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 1

DRAMP01811

    • At 60 ug/ml, the peptide showed about 1.3% hemolysis.

  • ·Literature 1
    • Title

    • Identification and characterization of two novel antimicrobial peptides, temporin-Ra and temporin-Rb, from skin secretions of the marsh frog (Rana ridibunda).
    • Reference

    • J Pept Sci. 2012 Jan;18(1):10-16.
    • Author

    • Asoodeh A, Zardini HZ, Chamani J.