General Information

    • DRAMP ID

    • DRAMP01811

    • Peptide Name

    • Temporin-Ra (Frogs, amphibians, animals)

    • Source

    • Rana ridibunda (marsh frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLKPLFNAALKLLP

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Escherichia coli (MIC=24.2 µg/ml), Klebsiella pneumoniae PTCC 1388 (MIC=31.2 µg/ml);
      • Gram-positive bacteria: Streptococcus dysgalactiae PTCC 1074 (MIC=33.2 µg/ml), Streptococcus agalactiae PTCC 1365 (MIC=24.7 µg/ml) and Staphylococcus aureus PTCC 1431 (MIC=35.2 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01811 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01811.

Physicochemical Information

    • Formula

    • C80H129N17O16

    • Absent Amino Acids

    • CDEGHIMQRSTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1585.01

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +2

    • Boman Index

    • 16.44

    • Hydrophobicity

    • 0.979

    • Aliphatic Index

    • 153.57

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP01811

Comments Information

    • At 60 ug/ml, the peptide showed about 1.3% hemolysis.

Literature Information

  • ·Literature 1

    • Title

    • Identification and characterization of two novel antimicrobial peptides, temporin-Ra and temporin-Rb, from skin secretions of the marsh frog (Rana ridibunda).

    • Reference

    • J Pept Sci. 2012 Jan;18(1):10-16.

    • Author

    • Asoodeh A, Zardini HZ, Chamani J.