General Information

    • DRAMP ID

    • DRAMP01815

    • Peptide Name

    • Temporin-GH (AMP-5; Frogs, amphibians, animals)

    • Source

    • Rana guentheri (Gunther's frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLPLLFGAISHLL

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus FDA209P (MIC=44.3 µg/ml), Bacillus subtilis ATCC 6633 (MIC>64 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01815 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01815.

Physicochemical Information

    • Formula

    • C73H113N15O15

    • Absent Amino Acids

    • CDEKMNQRTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1440.79

    • PI

    • 6.74

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +1

    • Boman Index

    • 30.17

    • Hydrophobicity

    • 1.915

    • Aliphatic Index

    • 187.69

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP01815

Comments Information

    • Function

    • Active against the Gram-positive bacteria S. aureus FDA209P and B. subtilis ATCC 6633, but not active against the Gram-negative bacteria E. coli or the fungus C. albicans.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • Leucine amide at position 13.

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri.

    • Reference

    • Peptides. 2006 Dec;27(12):3077-3084

    • Author

    • Zhou J, McClean S, Thompson A, Zhang Y, Shaw C, Rao P, Bjourson AJ.