• DRAMP ID

    • DRAMP01821
    • Peptide Name

    • Temporin-1Cc (Temporin 1Cc; Frogs, amphibians, animals)
    • Source

    • Rana clamitans (Green frog) (Lithobates clamitans)
    • Family

    • Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
    • Gene

    • Not found
    • Sequence

    • FLPFLASLLTKVL
    • Sequence Length

    • 13
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01821 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01821.
    • Formula

    • C74H120N14O16
    • Absent Amino Acids

    • CDEGHIMNQRWY
    • Common Amino Acids

    • L
    • Mass

    • 1461.85
    • PI

    • 8.75
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +1
    • Boman Index

    • 24.89
    • Hydrophobicity

    • 1.815
    • Aliphatic Index

    • 180
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 2

DRAMP01821

    • Function

    • Antibacterial activity against the Gram-positive bacterium Staphylococcus aureus.
    • Tissue specificity

    • Expressed by the skin glands.
  • ·Literature 1
    • Title

    • Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans.
    • Reference

    • Peptides. 2000 Apr;21(4):469-476.
    • Author

    • Halverson T, Basir YJ, Knoop FC, Conlon JM.