General Information
-
DRAMP ID
- DRAMP01823
-
Peptide Name
- Temporin-1Ce (Temporin 1Ce; Frogs, amphibians, animals)
-
Source
- Rana clamitans (Green frog) (Lithobates clamitans)
-
Family
- Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
-
Gene
- Not found
-
Sequence
- FLPFLATLLSKVL
-
Sequence Length
- 13
-
UniProt Entry
- P82884
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- [Ref.10822101] Gram-positive bacterium: Staphylococcus aureus (MIC=100 μM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01823.
Physicochemical Information
-
Formula
- C74H120N14O16
Absent Amino Acids
- CDEGHIMNQRWY
Common Amino Acids
- L
Mass
- 1461.85
PI
- 8.75
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- +1
-
Boman Index
- 24.89
Hydrophobicity
- 1.815
Aliphatic Index
- 180
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 2
DRAMP01823
Comments Information
Function
- Antibacterial activity against Gram-positive bacterium Staphylococcus aureus.
Tissue specificity
- Expressed by the skin glands.
Literature Information
- ·Literature 1
-
Title
- Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans.
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Pubmed ID
- 10822101
-
Reference
- Peptides. 2000 Apr;21(4):469-476.
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Author
- Halverson T, Basir YJ, Knoop FC, Conlon JM.