General Information

    • DRAMP ID

    • DRAMP01826

    • Peptide Name

    • RV-23 (Frogs, amphibians, animals)

    • Source

    • Rana aurora draytonii (California red-legged frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RIGVLLARLPKLFSLFKLMGKKV

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=12.5 μM), Staphylococcus epidermidis (MIC=3.13 μM), Bacillus subtilis (MIC=3.13 μM);
      • Gram-negative bacteria : Escherichia coli (MIC=6.25 μM), Pseudomonas aeruginosa (MIC=6.25 μM), Klebsiella pneumoniae (MIC=6.25 μM)

    • Hemolytic Activity

      • [Ref.27271216] 60% hemolysis at 20 μM , 90% hemolysis at 40 μM , 100% hemolysis at 60 μM , 100% hemolysis at 100 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01826 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01826.

Physicochemical Information

    • Formula

    • C126H219N33O25S

    • Absent Amino Acids

    • CDEHNQTWY

    • Common Amino Acids

    • L

    • Mass

    • 2628.39

    • PI

    • 12.03

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +6

    • Boman Index

    • -0.92

    • Hydrophobicity

    • 0.748

    • Aliphatic Index

    • 148.26

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP01826

DRAMP01826 chydropathy plot

Comments Information

    • [Ref.27271216]Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species.

    • Reference

    • Peptides. 2006 Jun;27(6):1305-1312.

    • Author

    • Conlon JM, Al-Ghafari N, Coquet L, Leprince J, Jouenne T, Vaudry H, Davidson C.
  • ·Literature 2

    • Title

    • Design of an α-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity

    • Reference

    • Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394.

    • Author

    • Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji