• DRAMP ID

    • DRAMP01827
    • Peptide Name

    • Temporin-1La (Temporin 1La; Frogs, amphibians, animals)
    • Source

    • Rana luteiventris (Spotted frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Unknown
    • Sequence

    • VLPLISMALGKLL
    • Sequence Length

    • 13
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • [Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=60 µM).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknownn
    • DRAMP01827 helical wheel diagram
    • Formula

    • C65H118N14O15S
    • Absent Amino Acids

    • CDEFHNQRTWY
    • Common Amino Acids

    • L
    • Mass

    • 1582.04
    • PI

    • 9.7
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Boman Index

    • 29.71
    • Hydrophobicity

    • 190
    • Aliphatic Index

    • 210
    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 2

DRAMP01827

    • Function

    • Antibacterial activity against Gram-positive bacteria.
    • Tissue specificity

    • Expressed by the skin glands.
    • PTM

    • Leucine amide at position 13.
  • Literature 1
    • Reference

    • Eur J Biochem. 2000 Feb;267(3):894-900.
    • Author

    • Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.
    • Title

    • Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.