General Information

    • DRAMP ID

    • DRAMP01827

    • Peptide Name

    • Temporin-1La (Temporin 1La; Frogs, amphibians, animals)

    • Source

    • Rana luteiventris (Spotted frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • N/A

    • Sequence

    • VLPLISMALGKLL

    • Sequence Length

    • 13

    • Evidence code

    • Protein level

Activity Information

    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial

    • Target Organism

      • [Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=60 µM).

    • Hemolytic Activity

      • N/A

    • Cytotoxicity

    • Binding Target

    • N/A

Structure Information

    • Linear/Cyclic/Branched

    • N-terminal modification

    • C-terminal modification

    • Other modifications

    • Stereochemistry

    • Structure

    • N/A

    • Structure Description

    • N/A
    • DRAMP01827 helical wheel diagram

Physical Information

    • Formula

    • C65H118N14O15S

    • Absent Amino Acids

    • CDEFHNQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 1582.04

    • PI

    • 9.7

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Boman Index

    • 29.71

    • Hydrophobicity

    • 190

    • Aliphatic Index

    • 210

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP01827

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • Leucine amide at position 13.

Literature Information

  • Literature 1

    • Reference

    • Eur J Biochem. 2000 Feb;267(3):894-900.

    • Author

    • Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.

    • Title

    • Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.