General Information

    • DRAMP ID

    • DRAMP01828

    • Peptide Name

    • Temporin-1Lb (Temporin 1Lb; Frogs, amphibians, animals)

    • Source

    • Rana luteiventris (Spotted frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • NFLGTLINLAKKIM

    • Sequence Length

    • 14

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • [Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=48 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • α-Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01828 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01828.

Physicochemical Information

    • Formula

    • C73H126N18O18S

    • Absent Amino Acids

    • CDEHPQRSVWY

    • Common Amino Acids

    • L

    • Mass

    • 1575.97

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +2

    • Boman Index

    • 5.73

    • Hydrophobicity

    • 0.786

    • Aliphatic Index

    • 146.43

    • Half Life

      • Mammalian:1.4 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01828

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • Methionine amide at position 14.

Literature Information

  • ·Literature 1

    • Title

    • Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.

    • Reference

    • Eur J Biochem. 2000 Feb;267(3):894-900.

    • Author

    • Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.