• DRAMP ID

    • DRAMP01829
    • Peptide Name

    • Temporin-1Lc (Temporin 1Lc; Frogs, amphibians, animals)
    • Source

    • Rana luteiventris (Spotted frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • N/A
    • Sequence

    • FLPILINLIHKGLL
    • Sequence Length

    • 14
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • [Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=125 µM).
    • Hemolytic Activity

      • N/A
    • Cytotoxicity

    • Binding Target

    • N/A
    • Linear/Cyclic/Branched

    • N-terminal modification

    • C-terminal modification

    • Other modifications

    • Stereochemistry

    • Structure

    • N/A
    • Structure Description

    • N/A
    • DRAMP01829 helical wheel diagram
    • Formula

    • C80H134N18O16
    • Absent Amino Acids

    • ACDEMQRSTVWY
    • Common Amino Acids

    • L
    • Mass

    • 1836.14
    • PI

    • 9.7
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Boman Index

    • 26.43
    • Hydrophobicity

    • 162.14
    • Aliphatic Index

    • 222.86
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 2

DRAMP01829

    • Function

    • Antibacterial activity against Gram-positive bacteria.
    • Tissue specificity

    • Expressed by the skin glands.
    • PTM

    • Leucine amide at position 14.
  • Literature 1
    • Reference

    • Eur J Biochem. 2000 Feb;267(3):894-900.
    • Author

    • Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.
    • Title

    • Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.