General Information

    • DRAMP ID

    • DRAMP01830

    • Peptide Name

    • Temporin-1P (Temporin-1M; Temporin-1CSa; Frogs, amphibians, animals)

    • Source

    • Rana pipiens (Northern leopard frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLPIVGKLLSGLL

    • Sequence Length

    • 13

    • Evidence code

    • Protein level

Activity Information

    • Biological Activity

    • Antibacterial,Anti-Gram+, Antimicrobial

    • Target Organism

      • [Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=110 µM).

    • Hemolytic Activity

      • Not found

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Other Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found
    • DRAMP01830 helical wheel diagram

Physicochemical Information

    • Formula

    • Absent Amino Acids

    • Common Amino Acids

    • Mass

    • 0

    • PI

    • 0

    • Basic Residues

    • Acidic Residues

    • Hydrophobic Residues

    • Boman Index

    • 0

    • Hydrophobicity

    • 0

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:
      • Yeast:
      • E.coli:

    • Extinction Coefficient Cystines

    • Absorbance 280nm

    • 0

    • Polar Residues

DRAMP01830

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • Leucine amide at position 13.

    • It is also found in North American frog Rana cascadae and named as temporin-1CSa (Conlon et al 2007 Peptides 28

    • 1268-1274). It is also found in the mountain yellow-legged frog Rana muscosa and named as temporin-1M (Rollins-Smith LA et al. 2002 Dev Comp Immunol 26

Literature Information

  • ·Literature 1

    • Title

    • Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.

    • Reference

    • Eur J Biochem. 2000 Feb;267(3):894-900.

    • Author

    • Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.
  • ·Literature 2

    • Title

    • Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group.

    • Reference

    • Peptides 2007; 28: 1268-1274.

    • Author

    • Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C.