General Information
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DRAMP ID
DRAMP01830
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Peptide Name
Temporin-1P (Temporin-1M; Temporin-1CSa; Frogs, amphibians, animals)
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Source
Rana pipiens (Northern leopard frog)
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Family
Belongs to the frog skin active peptide family (Brevinin subfamily)
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Gene
Unknown
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Sequence
FLPIVGKLLSGLL
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Sequence Length
13
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Swiss_Prot Entry
P82848
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Evidence code
Protein level
Activity Information
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Biological Activity
Antibacterial,Anti-Gram+, Antimicrobial
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Target Organism
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- [Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=110 µM).
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Hemolytic activity
- Unknown
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Binding Target
Unknown
Structure Information
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Structure
Unknown
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Structure Description
Unknownn
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PDB ID
Unknown
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-
Physical Information
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Formula
Absent Amino Acids
Common Amino Acids
Mass
0
PI
0
Basic Residues
Acidic Residues
Hydrophobic Residues
-
Boman Index
0
Hydrophobicity
0
Aliphatic Index
0
Half Life
-
- Mammalian:
- Yeast:
- E.coli:
Extinction Coefficient Cystines
Absorbance 280nm
0
Polar Residues
DRAMP01830
Comments Information
Function
Antibacterial activity against Gram-positive bacteria.
Tissue specificity
Expressed by the skin glands.
PTM
Leucine amide at position 13.
It is also found in North American frog Rana cascadae and named as temporin-1CSa (Conlon et al 2007 Peptides 28
1268-1274). It is also found in the mountain yellow-legged frog Rana muscosa and named as temporin-1M (Rollins-Smith LA et al. 2002 Dev Comp Immunol 26
Literature Information
- Literature 1
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Pubmed ID
10651828
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Reference
Eur J Biochem. 2000 Feb;267(3):894-900.
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Author
Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.
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Title
Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.
- Literature 2
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Pubmed ID
17451843
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Reference
Peptides 2007; 28: 1268-1274.
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Author
Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C.
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Title
Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group.