General Information
-
DRAMP ID
- DRAMP01832
-
Peptide Name
- Temporin-Eca (Frogs, amphibians, animals)
-
Source
- Euphlyctis cyanophlyctis (Skittering frog)
-
Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- FLPGLLAGLL
-
Sequence Length
- 10
-
UniProt Entry
- C0HJB9
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Swiss_Prot Entry C0HJB9]Gram-negative bacteria: Escherichia coli HP101BA (MIC=12.3 µM), Klebsiella pneumoniae PTCC1388 (MIC=9.8 µM);
- Gram-positive bacteria: Micrococcus luteus PTCC1625 (MIC=8.3 µM), Staphylococcus aureus PTCC1431 (MIC=10.6 µM).
-
Hemolytic Activity
-
- [Ref.Int J Pept Res Ther(2012)18;107.]<3% hemolytic activity at 60 µg/ml against human red blood cells
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01832.
Physicochemical Information
-
Formula
- C51H84N10O11
Absent Amino Acids
- CDEHIKMNQRSTVWY
Common Amino Acids
- L
Mass
- 1013.29
PI
- 5.52
Basic Residues
- 0
Acidic Residues
- 0
Hydrophobic Residues
- 7
Net Charge
- 0
-
Boman Index
- 31.27
Hydrophobicity
- 2.12
Aliphatic Index
- 205
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 2
DRAMP01832
Comments Information
Function
- Has antibacterial activity. Has no or very limited (<3%) hemolytic activity at concentrations of 15 µg/ml and 60 µg/ml, respectively.
Tissue specificity
- Expressed by the skin glands.
Literature Information
- ·Literature 1
-
Title
- Identification and characterization of novel antibacterial peptides from skin secretions of Euphlyctis cyanophlyctis.
-
Pubmed ID
- PubMed ID is not available
-
Reference
- Int. J. Pept. Res. Ther. 2012;18:107-115.
-
Author
- Asoodeh A, Ghorani-Azam A, Chamani JK.