• • DRAMP ID

  • DRAMP01834

• • Peptide Name

  • Cyanophlyctin (Frogs, amphibians, animals)

• • Source

  • Euphlyctis cyanophlyctis (Skittering frog)

• • Family

  • Belongs to the frog skin active peptide family (Brevinin subfamily)

• • Gene

  • Not found

• • Sequence

  • FLNALKNFAKTAGKRLKSLLN

• • Sequence Length

  • 21

• • UniProt Entry

  • C0HJB8

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Swiss_Prot Entry C0HJB8]Gram-negative bacteria: Escherichia coli HP101BA (MIC=6.4 µM), Klebsiella pneumoniae PTCC1388 (MIC=7.3 µM);
    • Gram-positive bacteria: Micrococcus luteus PTCC1625 (MIC=4.7 µM), Staphylococcus aureus PTCC1431 (MIC=5.3 µM).

• • Hemolytic Activity

  • • [Ref.Int J Pept Res Ther(2012)18;107.]<3% hemolytic activity at 60 µg/ml against human red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP01834.

DRAMP01834

• • Function

  • Has antibacterial activity. Has no or very limited (<3%) hemolytic activity at concentrations of 15 µg/ml and 60 µg/ml.

• • Tissue specificity

  • Expressed by the skin glands.

• ·Literature 1

• • Title

  • Identification and characterization of novel antibacterial peptides from skin secretions of Euphlyctis cyanophlyctis.

• • Pubmed ID

  • PubMed ID is not available

• • Reference

  • Int. J. Pept. Res. Ther. 2012;18:107-115.

• • Author

  • oodeh A, Ghorani-Azam A, Chamani JK.