• DRAMP ID

    • DRAMP01869
    • Peptide Name

    • Brevinin-1SPa (Frogs, amphibians, animals)
    • Source

    • Rana septentrionalis (mink frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • FFPIIAGMAAKLIPSLFCKITKKC
    • Sequence Length

    • 24
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=13 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=6 µM);
      • Yeast: Candida albicans (MIC=7 µM).
    • Hemolytic Activity

      • [Ref.15556063]HC50=7 µM against human erythrocytes
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01869 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C126H206N28O27S3
    • Absent Amino Acids

    • DEHNQRVWY
    • Common Amino Acids

    • IK
    • Mass

    • 2641.37
    • PI

    • 9.7
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 12
    • Net Charge

    • +4
    • Boman Index

    • 21.57
    • Hydrophobicity

    • 1.067
    • Aliphatic Index

    • 110
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 5.43
    • Polar Residues

    • 5

DRAMP01869

DRAMP01869 chydropathy plot
    • Function

    • Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes.
  • ·Literature 1
    • Title

    • Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis).
    • Reference

    • Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38.
    • Author

    • Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM.