General Information

    • DRAMP ID

    • DRAMP01870

    • Peptide Name

    • Brevinin-1SPb (Frogs, amphibians, animals)

    • Source

    • Rana septentrionalis (mink frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLPIIAGMAAKVICAITKKC

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=50 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=13 µM);
      • Yeast: Candida albicans (MIC=25 µM).

    • Hemolytic Activity

      • [Ref.15556063]HC50=25 µM against human erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01870 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C96H167N23O22S3

    • Absent Amino Acids

    • DEHNQRSWY

    • Common Amino Acids

    • AI

    • Mass

    • 2091.7

    • PI

    • 9.39

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • 25.49

    • Hydrophobicity

    • 1.425

    • Aliphatic Index

    • 132

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 6.58

    • Polar Residues

    • 4

DRAMP01870

DRAMP01870 chydropathy plot

Comments Information

    • Function

    • Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes (HC50=6 µM).

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis).

    • Reference

    • Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38.

    • Author

    • Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM.