• DRAMP ID

    • DRAMP01880
    • Peptide Name

    • Brevinin-2LTb (Frogs, amphibians, animals)
    • Source

    • Hylarana latouchii (Broad-folded frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • SILDKIKNVALGVARGAGTGILKALLCKLDKSC
    • Sequence Length

    • 33
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=3.8 µM), Bacillus licheniformis X39 (MIC=3.8 µM), Staphylococcus carnosus KHS (MIC=1.9 µM), Rhodococcus rhodochrous X15 (MIC=1.9 µM);
      • Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=30 µM), Serratia rubidaea X01 (MIC=60 µM), Pseudomonas aeruginosa 1.50 (MIC=30 µM), Psychrobacter faecalis X29 (MIC=1.9 µM).
    • Hemolytic Activity

      • [Ref.22426384] LD50=480 μM against human erythrocytes
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys27 and Cys33)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys27 and Cys33.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01880 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C148H266N42O42S2
    • Absent Amino Acids

    • EFHMPQWY
    • Common Amino Acids

    • L
    • Mass

    • 3370.12
    • PI

    • 9.59
    • Basic Residues

    • 6
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 15
    • Net Charge

    • +4
    • Boman Index

    • -10.2
    • Hydrophobicity

    • 0.561
    • Aliphatic Index

    • 136.06
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 3.91
    • Polar Residues

    • 10

DRAMP01880

DRAMP01880 chydropathy plot
    • Comment

    • No comments found on DRAMP database
  • ·Literature 1
    • Title

    • Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii.
    • Reference

    • Biochimie. 2012 Jun;94(6):1317-1326.
    • Author

    • Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J.