General Information
-
DRAMP ID
- DRAMP01886
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Peptide Name
- Brevinin-2TEa (Frogs, amphibians, animals)
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Source
- Hylarana temporalis (Indian bronzed frog)
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Family
- Not found
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Gene
- Not found
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Sequence
- GIGSMLLGLAKNVGMSLLNKAQCKISGKC
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Sequence Length
- 29
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UniProt Entry
- No entry found
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-negative bacteria: E. coli (NCLM 2064) (MIC=40 µg/ml), P. aeruginosa (ATCC 10145) (MIC=100 µg/ml), V. cholerae (PL 91) (MIC=150 µg/ml);
- Gram-positive bacteria: B. cereus (NCLM 2156) (MIC>150 µg/ml), S. aureus (ATCC25923) (MIC>150 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01886.
Physicochemical Information
-
Formula
- C125H224N36O36S4
Absent Amino Acids
- DEFHPRTWY
Common Amino Acids
- GL
Mass
- 2935.61
PI
- 9.7
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 10
Net Charge
- +4
-
Boman Index
- 2.84
Hydrophobicity
- 0.486
Aliphatic Index
- 111.03
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 4.46
Polar Residues
- 12
DRAMP01886
Comments Information
Function
- Showes higher antimicrobial activity against Gram-negative than against Gram-positive bacteria.
Literature Information
- ·Literature 1
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Title
- Three novel antimicrobial peptides from the skin of the Indian bronzed frog Hylarana temporalis (Anura: Ranidae).
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Pubmed ID
- 21412958
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Reference
- J Pept Sci. 2011 May;17(5):342-347.
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Author
- Reshmy V, Preeji V, Parvin A, Santhoshkumar K, George S.