General Information
-
DRAMP ID
- DRAMP01888
-
Peptide Name
- Brevinin-1CHc (Frogs, amphibians, animals)
-
Source
- Rana chiricahuensis
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- FFPTIAGLTKLFCAITKKC
-
Sequence Length
- 19
-
UniProt Entry
- No entry found
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-negative bacterium: E. coli (MIC=80 µM);
- Gram-positive bacterium: S. aureus (MIC=20 µM).
- Yeast: C. albicans (MIC=20 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Free
-
C-terminal Modification
- Cyclization (Cys13 and Cys19)
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Nonterminal Modifications and Unusual Amino Acids
- Disulfide bond between Cys13 and Cys19.
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01888.
Physicochemical Information
-
Formula
- C100H160N22O23S2
Absent Amino Acids
- DEHMNQRSVWY
Common Amino Acids
- FKT
Mass
- 2102.62
PI
- 9.39
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- +3
-
Boman Index
- 11.38
Hydrophobicity
- 0.937
Aliphatic Index
- 92.63
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 6.94
Polar Residues
- 6
DRAMP01888
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona.
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Pubmed ID
- 21262304
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Reference
- Peptides. 2011 Apr;32(4):664-669.
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Author
- Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD.