• DRAMP ID

    • DRAMP01892
    • Peptide Name

    • Brevinin-1VLd (Frogs, amphibians, animals)
    • Source

    • Rana vaillanti (Central American frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • FLPLIAGVAANFLPKIFCLISKKC
    • Sequence Length

    • 24
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-negative bacterium: E. coli (MIC>100 µM);
      • Gram-positive bacterium: S. aureus (MIC=3 µM).
      • Yeast: C. albicans (MIC=3 µM).
    • Hemolytic Activity

      • [Ref.19379837] LC50=5 mM against human erythrocytes
    • Cytotoxicity

      • [Ref.19379837] LC50=6mM against HepG2 hepatoma-derived cells
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys18 and Cys24)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys18 and Cys24.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01892 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01892.
    • Formula

    • C126H204N28O27S2
    • Absent Amino Acids

    • DEHMQRTWY
    • Common Amino Acids

    • L
    • Mass

    • 2607.3
    • PI

    • 9.39
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 14
    • Net Charge

    • +3
    • Boman Index

    • 29.66
    • Hydrophobicity

    • 1.338
    • Aliphatic Index

    • 138.33
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 5.43
    • Polar Residues

    • 5

DRAMP01892

DRAMP01892 chydropathy plot
    • Function

    • Inhibits the growth of reference strains of S. aureus, E. coli and C. albicans and to lyse human erythrocytes from a healthy donor and HepG2 human hepatoma-derived cells
  • ·Literature 1
    • Title

    • Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae).
    • Reference

    • Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154.
    • Author

    • Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD.