General Information

    • DRAMP ID

    • DRAMP01900

    • Peptide Name

    • Brevinin-1CG5 (Frogs, amphibians, animals)

    • Source

    • Amolops chunganensis (Chungan torrent frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLPMLAGLAANFLPKIVCKITKKC

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=0.6 µM), Bacillus licheniformis X39 (IS) (MIC=2.3 µM), Enterococcus faecalis 981 (MIC=9 µM), Staphylococcus carnosus KHS (IS) (MIC=1.2 µM), Staphylococcus aureus (ATCC 25923) (MIC=9 µM);
      • Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=75 µM), Pseudomonas aeruginosa (CGMCC 1.50) (MIC=75 µM), Pseudomonas aeruginosa 11053 (IS) (MIC=75 µM), Klebsiella pneumoniae 08040724 (IS) (MIC=150 µM), Psychrobacter faecalis X29 (IS) (MIC=9 µM), Serratia rubidaea X01 (IS) (MIC=4.6 µM).
      • Fungi: Slime mold 090223 (IS) (MIC=4.5 µM), Candida albicans (ATCC 10231) (MIC=437.5 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01900 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C123H207N29O27S3

    • Absent Amino Acids

    • DEHQRSWY

    • Common Amino Acids

    • KL

    • Mass

    • 2620.35

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +4

    • Boman Index

    • 19.39

    • Hydrophobicity

    • 0.954

    • Aliphatic Index

    • 122.08

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.43

    • Polar Residues

    • 5

DRAMP01900

DRAMP01900 chydropathy plot

Comments Information

    • Function

    • Primarily active against Gram-positive bacteria, escecially R. rhodochrous. Also highly active against Gram-negative P. faecalis X29 and S. rubidaea.

Literature Information

  • ·Literature 1

    • Title

    • Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis.

    • Reference

    • Peptides. 2012 Nov;38(1):41-53.

    • Author

    • Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H.