General Information

    • DRAMP ID

    • DRAMP01908

    • Peptide Name

    • Brevinin 2Ta (Frogs, amphibians, animals)

    • Source

    • Rana temporaria (European common frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GILDTLKNLAKTAGKGILKSLVNTASCKLSGQC

    • Sequence Length

    • 33

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01908 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01908.

Physicochemical Information

    • Formula

    • C144H257N41O45S2

    • Absent Amino Acids

    • EFHMPRWY

    • Common Amino Acids

    • L

    • Mass

    • 3346.99

    • PI

    • 9.6

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +4

    • Boman Index

    • -18.05

    • Hydrophobicity

    • 0.206

    • Aliphatic Index

    • 112.42

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 3.91

    • Polar Residues

    • 14

DRAMP01908

DRAMP01908 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptide.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • Problely contains one disulfide bond 27-33.

Literature Information

  • ·Literature 1

    • Title

    • A cDNA clone encoding brevinin 2Ta from Rana temporaria.

    • Reference

    • Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.

    • Author

    • Simmaco M, Miele R, Mangoni M.L, Barra D.