General Information

    • DRAMP ID

    • DRAMP01917

    • Peptide Name

    • Brevinin-1PLa (Frogs, amphibians, animals)

    • Source

    • Rana palustris (Pickerel frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FFPNVASVPGQVLKKIFCAISKKC

    • Sequence Length

    • 24

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01917 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01917.

Physicochemical Information

    • Formula

    • C123H198N30O29S2

    • Absent Amino Acids

    • DEHMRTWY

    • Common Amino Acids

    • K

    • Mass

    • 2625.23

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +4

    • Boman Index

    • 1.76

    • Hydrophobicity

    • 0.608

    • Aliphatic Index

    • 93.33

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.43

    • Polar Residues

    • 6

DRAMP01917

DRAMP01917 chydropathy plot

Comments Information

    • Inhibit the growth of Batrachochytrium dendrobatidis (Bd) (MIC=50 µM), a fungus that might have played a role in killing many frogs.

Literature Information

  • ·Literature 1

    • Title

    • Balancing selection at a frog antimicrobial peptide locus: fluctuating immune effector alleles?

    • Reference

    • Mol Biol Evol. 2008 Dec;25(12):2669-2680.

    • Author

    • Tennessen JA, Blouin MS.
  • ·Literature 2

    • Title

    • Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris.

    • Reference

    • Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.

    • Author

    • Basir YJ, Knoop FC, Dulka J, Conlon JM.