General Information

    • DRAMP ID

    • DRAMP01926

    • Peptide Name

    • Brevinin-1Ec (Frogs, amphibians, animals)

    • Source

    • Rana ridibunda (Laughing frog) (Marsh frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLPLLAGLAANFFPKIFCKITRKC

    • Sequence Length

    • 24

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

    • [Swiss_Prot Entry P86150]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species

    • Hemolytic Activity

      • [Ref.18855342]show hemolytic activity

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01926 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01926.

Physicochemical Information

    • Formula

    • C131H207N31O27S2

    • Absent Amino Acids

    • DEHMQSVWY

    • Common Amino Acids

    • FL

    • Mass

    • 2712.4

    • PI

    • 9.85

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +4

    • Boman Index

    • 9.59

    • Hydrophobicity

    • 0.908

    • Aliphatic Index

    • 110

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.43

    • Polar Residues

    • 5

DRAMP01926

DRAMP01926 chydropathy plot

Comments Information

    • Function

    • Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • De novo sequencing of peptides secreted by the skin glands of the Caucasian Green Frog Rana ridibunda.

    • Reference

    • Rapid Commun Mass Spectrom. 2008 Nov;22(22):3517-3525.

    • Author

    • Samgina TY, Artemenko KA, Gorshkov VA, Ogourtsov SV, Zubarev RA, Lebedev AT.