General Information
-
DRAMP ID
- DRAMP01938
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Peptide Name
- CPRF-Eb (caerulein precursor-related fragment; Frogs, amphibians, animals)
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Source
- Rana esculenta complex
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Family
- Not found
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Gene
- Not found
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Sequence
- GLGSFLKNAIKIAGKVGSTIGKVADAIGNKE
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Sequence Length
- 31
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UniProt Entry
- No entry found
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Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
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Target Organism
-
- Gram-negative bacterium: Escherichia coli (MIC=5 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP01938_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C136H234N38O41
Absent Amino Acids
- CHMPQRWY
Common Amino Acids
- G
Mass
- 3057.58
PI
- 9.83
Basic Residues
- 5
Acidic Residues
- 2
Hydrophobic Residues
- 13
Net Charge
- +3
-
Boman Index
- -12.47
Hydrophobicity
- 0.187
Aliphatic Index
- 107.1
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 11
DRAMP01938
Comments Information
Function
- Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 µM, inhibited the growth of the fungal pathogen C. albicans.
Sequence similarity
- This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide.
Literature Information
- ·Literature 1
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Title
- Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex.
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Pubmed ID
- 14499272
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Reference
- Peptides. 2003 Jul;24(7):955-961.
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Author
- Ali MF, Knoop FC, Vaudry H, Conlon JM.