General Information
-
DRAMP ID
- DRAMP01951
-
Peptide Name
- Brevinin-1PTa (Frogs, amphibians, animals)
-
Source
- Rana picturata (Malaysian fire frog) (Hylarana picturata)
-
Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- FMGGLIKAATKIVPAAYCAITKKC
-
Sequence Length
- 24
-
UniProt Entry
- P0C8T1
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 µM);
- Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=24 µM).
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Hemolytic Activity
-
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Free
-
C-terminal Modification
- Cyclization (Cys18 and Cys24)
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Nonterminal Modifications and Unusual Amino Acids
- Disulfide bond between Cys18 and Cys24.
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Stereochemistry
- L
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP01951_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C114H192N28O28S3
Absent Amino Acids
- DEHNQRSW
Common Amino Acids
- A
Mass
- 2499.13
PI
- 9.6
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +4
-
Boman Index
- 15.06
Hydrophobicity
- 0.813
Aliphatic Index
- 97.92
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 1615
Absorbance 280nm
- 70.22
Polar Residues
- 7
DRAMP01951
Comments Information
Function
- Has antibacterial activity.
Tissue specificity
- Expressed by the skin glands.
PTM
- Contains one disulfide bond 18-24.
Literature Information
- ·Literature 1
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Title
- Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).
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Pubmed ID
- 18621071
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Reference
- Toxicon. 2008 Sep 1;52(3):465-473.
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Author
- Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD.