• DRAMP ID

    • DRAMP01952
    • Peptide Name

    • Brevinin-1PTb (Frogs, amphibians, animals)
    • Source

    • Rana picturata (Malaysian fire frog) (Hylarana picturata)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • FMGGLIKAATKALPAAFCAITKKC
    • Sequence Length

    • 24
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus ATCC 25923;
      • Gram-negative bacterium: Escherichia coli ATCC 25726.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01952 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01952.
    • Formula

    • C112H188N28O27S3
    • Absent Amino Acids

    • DEHNQRSVWY
    • Common Amino Acids

    • A
    • Mass

    • 2455.08
    • PI

    • 9.7
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 12
    • Net Charge

    • +4
    • Boman Index

    • 15.95
    • Hydrophobicity

    • 0.854
    • Aliphatic Index

    • 90
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 5.43
    • Polar Residues

    • 6

DRAMP01952

DRAMP01952 chydropathy plot
    • Function

    • Has antibacterial activity.
    • Tissue specificity

    • Expressed by the skin glands.
    • PTM

    • Contains one disulfide bond 18-24.
  • ·Literature 1
    • Title

    • Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).
    • Reference

    • Toxicon. 2008 Sep 1;52(3):465-473.
    • Author

    • Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD.