General Information
-
DRAMP ID
- DRAMP01954
-
Peptide Name
- Brevinin-2HSb (Frogs, amphibians, animals)
-
Source
- Odorrana hosii (Hose's rock frog) (Rana hosii)
-
Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- GLLDTLKNMAINAAKGAGQSVLNTLSCKLSKTC
-
Sequence Length
- 33
-
UniProt Entry
- P0C8T0
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacterium: Staphylococcus aureus ATCC 25923;
- Gram-negative bacterium: Escherichia coli ATCC 25726.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01954.
Physicochemical Information
-
Formula
- C142H251N41O46S3
Absent Amino Acids
- EFHPRWY
Common Amino Acids
- L
Mass
- 3364.98
PI
- 9.31
Basic Residues
- 4
Acidic Residues
- 1
Hydrophobic Residues
- 12
Net Charge
- +3
-
Boman Index
- -20.84
Hydrophobicity
- 0.206
Aliphatic Index
- 103.64
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 3.91
Polar Residues
- 14
DRAMP01954
Comments Information
Function
- Has antibacterial activity.
Tissue specificity
- Expressed by the skin glands.
PTM
- Contains one disulfide bond 27-33.
Literature Information
- ·Literature 1
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Title
- Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).
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Pubmed ID
- 18621071
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Reference
- Toxicon. 2008 Sep 1;52(3):465-473.
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Author
- Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD.