• DRAMP ID

    • DRAMP01955
    • Peptide Name

    • Brevinin-2PTa (Frogs, amphibians, animals)
    • Source

    • Rana picturata (Malaysian fire frog) (Hylarana picturata)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • GAIKDALKGAAKTVAVELLKKAQCKLEKTC
    • Sequence Length

    • 30
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=18 µM);
      • Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=18 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys24 and Cys30)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys24 and Cys30.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01955 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C137H246N38O40S2
    • Absent Amino Acids

    • FHMNPRSWY
    • Common Amino Acids

    • K
    • Mass

    • 3129.81
    • PI

    • 9.45
    • Basic Residues

    • 7
    • Acidic Residues

    • 3
    • Hydrophobic Residues

    • 13
    • Net Charge

    • +4
    • Boman Index

    • -23.89
    • Hydrophobicity

    • 0.013
    • Aliphatic Index

    • 104.33
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 4.31
    • Polar Residues

    • 6

DRAMP01955

DRAMP01955 chydropathy plot
    • Function

    • Has antibacterial activity.
    • Tissue specificity

    • Expressed by the skin glands.
    • PTM

    • Contains one disulfide bond 24-30.
  • ·Literature 1
    • Title

    • Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).
    • Reference

    • Toxicon. 2008 Sep 1;52(3):465-473.
    • Author

    • Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD.