• DRAMP ID

    • DRAMP01958
    • Peptide Name

    • Brevinin-2PTd (Frogs, amphibians, animals)
    • Source

    • Rana picturata (Malaysian fire frog) (Hylarana picturata)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • GFLDSFKNAMIGVAKSAGKTALNTLACKIDKTC
    • Sequence Length

    • 33
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus ATCC 25923;
      • Gram-negative bacterium: Escherichia coli ATCC 25726.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys27 and Cys33)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys27 and Cys33.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01958 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01958.
    • Formula

    • C149H250N40O45S3
    • Absent Amino Acids

    • EHPQRWY
    • Common Amino Acids

    • AK
    • Mass

    • 3418.04
    • PI

    • 9.24
    • Basic Residues

    • 5
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 13
    • Net Charge

    • +3
    • Boman Index

    • -21.6
    • Hydrophobicity

    • 0.233
    • Aliphatic Index

    • 83.03
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 3.91
    • Polar Residues

    • 12

DRAMP01958

DRAMP01958 chydropathy plot
    • Function

    • Has antibacterial activity.
    • Tissue specificity

    • Expressed by the skin glands.
    • PTM

    • Contains one disulfide bond 27-33.
  • ·Literature 1
    • Title

    • Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).
    • Reference

    • Toxicon. 2008 Sep 1;52(3):465-473.
    • Author

    • Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD.