• • DRAMP ID

  • DRAMP01967

• • Peptide Name

  • Brevinin-1Yb (Frogs, amphibians, animals)

• • Source

  • Lithobates yavapaiensis (North America leopard frog)

• • Family

  • Belongs to the frog skin active peptide family (Brevinin subfamily)

• • Gene

  • Not found

• • Sequence

  • FLPIIAGAAAKVVQKIFCAISKKC

• • Sequence Length

  • 24

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.19254736] Gram-positive bacteria : Staphylococcus aureus(MIC=3 μM);
    • Gram-negative bacteria : Escherichia coli(MIC=25 μM);
    • Fungi : Candida albicans(MIC=3 μM)

• • Hemolytic Activity

  • • [Ref.19254736] LC50=16 μM against human red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP01967_predicted_structure.pdb to download.

DRAMP01967

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans

• ·Literature 1

• • Title

  • Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis.

• • Pubmed ID

  • 19254736

• • Reference

  • Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.

• • Author

  • Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD.