General Information

    • DRAMP ID

    • DRAMP01968

    • Peptide Name

    • Brevinin-1Yc (Frogs, amphibians, animals)

    • Source

    • Lithobates yavapaiensis (North American leopard frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLPIIAGAAAKVVEKIFCAISKKC

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.19254736] Gram-positive bacteria : Staphylococcus aureus(MIC=6 μM);
      • Gram-negative bacteria : Escherichia coli(MIC=100 μM);
      • Fungi : Candida albicans(MIC=6 μM)Gram-negative bacterium: Escherichia coli (MIC=100 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=6 µM).
      • Yeast: Candida albicans (MIC=6 µM).
      • cancer cells HepG2 (LC50=14 µM).

    • Hemolytic Activity

      • [Ref.19254736] LC50=13 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01968 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C118H198N28O28S2

    • Absent Amino Acids

    • DHMNQRTWY

    • Common Amino Acids

    • A

    • Mass

    • 2521.16

    • PI

    • 9.31

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +3

    • Boman Index

    • 18.78

    • Hydrophobicity

    • 1.163

    • Aliphatic Index

    • 126.25

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.43

    • Polar Residues

    • 4

DRAMP01968

DRAMP01968 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans

Literature Information

  • ·Literature 1

    • Title

    • Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis.

    • Reference

    • Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.

    • Author

    • Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD.