• • DRAMP ID

  • DRAMP01969

• • Peptide Name

  • Brevinin-1Ja (Frogs, amphibians, animals)

• • Source

  • Rana japonica (Japanese brown frog)

• • Family

  • Belongs to the frog skin active peptide family (Brevinin subfamily)

• • Gene

  • Not found

• • Sequence

  • FLGSLIGAAIPAIKQLLGLKK

• • Sequence Length

  • 21

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • Gram-positive bacterium: Staphylococcus aureus (MIC=15 µM);
    • Gram-negative bacterium: Escherichia coli (MIC=119 µM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP01969_predicted_structure.pdb to download.

DRAMP01969

• • It can produced cell death of mammalian COS7 cells (LD50=28 µM).

• ·Literature 1

• • Title

  • Molecular cloning of a cDNA encoding atypical antimicrobial and cytotoxic brevinin-1Ja from the skin of the Japanese brown frog, Rana japonica.

• • Pubmed ID

  • 18558801

• • Reference

  • Zoolog Sci 2008; 25: 487-491.

• • Author

  • Koyama T, Iwamuro S.