General Information
-
DRAMP ID
- DRAMP01970
-
Peptide Name
- Brevinin-1ZHa (Frogs, amphibians, animals)
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Source
- Rana zhenhaiensis (Chinese brown frog)
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
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Gene
- Not found
-
Sequence
- FLPFLLSALPKVFCFFSKKC
-
Sequence Length
- 20
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=8 µM);
- Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=16 µM), Pseudomonas aeruginosa ATCC 9027 (MIC=32 µM).
- Yeast: Candida albicans ATCC 2002 (MIC>43 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01970.
Physicochemical Information
-
Formula
- C117H175N23O23S2
Absent Amino Acids
- DEGHIMNQRTWY
Common Amino Acids
- F
Mass
- 2335.94
PI
- 9.39
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +3
-
Boman Index
- 19.54
Hydrophobicity
- 1.185
Aliphatic Index
- 97.5
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 6.58
Polar Residues
- 4
DRAMP01970
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis.
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Pubmed ID
- 22943778
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Reference
- Zoolog Sci. 2012 Sep;29(9):553-558.
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Author
- Xu B, Che H, Kang L, Zheng S, Mu S, Wan F.