General Information
-
DRAMP ID
- DRAMP01974
-
Peptide Name
- Brevinin-2ZHa (Frogs, amphibians, animals)
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Source
- Rana zhenhaiensis (Chinese brown frog)
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
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Gene
- Not found
-
Sequence
- GIMRVFKGVLKTAGKSVAKNVAGSFLDRLKCKISGGC
-
Sequence Length
- 37
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UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=1 µM);
- Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5 µM), Pseudomonas aeruginosa ATCC 9027 (MIC=5 µM).
- Yeast: Candida albicans ATCC 2002 (MIC=3 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01974.
Physicochemical Information
-
Formula
- C169H292N50O45S3
Absent Amino Acids
- EHPQWY
Common Amino Acids
- GK
Mass
- 3840.67
PI
- 10.32
Basic Residues
- 8
Acidic Residues
- 1
Hydrophobic Residues
- 14
Net Charge
- +7
-
Boman Index
- -28.57
Hydrophobicity
- 0.276
Aliphatic Index
- 92.16
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 3.47
Polar Residues
- 13
DRAMP01974
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis.
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Pubmed ID
- 22943778
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Reference
- Zoolog Sci. 2012 Sep;29(9):553-558.
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Author
- Xu B, Che H, Kang L, Zheng S, Mu S, Wan F.