General Information
-
DRAMP ID
- DRAMP01981
-
Peptide Name
- Brevinin-2Rc (Frogs, amphibians, animals)
-
Source
- Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
-
Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- GLMSTLKGAATNVAVTLLNKLQCKLTGTC
-
Sequence Length
- 29
-
UniProt Entry
- P86024
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01981.
Physicochemical Information
-
Formula
- C126H225N35O39S3
Absent Amino Acids
- DEFHIPRWY
Common Amino Acids
- L
Mass
- 2950.56
PI
- 9.39
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +3
-
Boman Index
- -0.96
Hydrophobicity
- 0.545
Aliphatic Index
- 111.03
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 4.46
Polar Residues
- 13
DRAMP01981
Comments Information
Function
- Antimicrobial peptide. (By similarity)
Tissue specificity
- Expressed by the skin glands.
PTM
- contains one disulfide bond 23-29.
Literature Information
- ·Literature 1
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Title
- De novo sequencing of peptides secreted by the skin glands of the Caucasian Green Frog Rana ridibunda.
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Pubmed ID
- 18855342
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Reference
- Rapid Commun Mass Spectrom. 2008 Nov;22(22):3517-3525.
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Author
- Samgina TY, Artemenko KA, Gorshkov VA, Ogourtsov SV, Zubarev RA, Lebedev AT.