General Information

    • DRAMP ID

    • DRAMP01984

    • Peptide Name

    • Brevinin-1HS2 (Frogs, amphibians, animals)

    • Source

    • Huia schmackeri (Chinese piebald odorous frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLPLIASVAANLAPKIICKITKTC

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01984 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01984.

Physicochemical Information

    • Formula

    • C117H202N28O29S2

    • Absent Amino Acids

    • DEGHMQRWY

    • Common Amino Acids

    • AI

    • Mass

    • 2529.18

    • PI

    • 9.39

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +3

    • Boman Index

    • 19.43

    • Hydrophobicity

    • 1.167

    • Aliphatic Index

    • 142.5

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.43

    • Polar Residues

    • 6

DRAMP01984

DRAMP01984 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptide homologs.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Novel brevinins from Chinese piebald odorous frog (Huia schmackeri) skin deduced from cloned biosynthetic precursors.

    • Reference

    • Peptides. 2008 Aug;29(8):1456-1460.

    • Author

    • Quan Z, Zhou M, Chen W, Chen T, Walker B, Shaw C.