• • DRAMP ID

  • DRAMP01986

• • Peptide Name

  • Brevinin-2HS2 (Frogs, amphibians, animals)

• • Source

  • Huia schmackeri (Chinese piebald odorous frog)

• • Family

  • Belongs to the frog skin active peptide family (Brevinin subfamily)

• • Gene

  • Not found

• • Sequence

  • SLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC

• • Sequence Length

  • 33

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=19 µM), Bacillus licheniformis X39 (MIC=39 µM), Rhodococcus rhodochrous X15 (MIC=9.5 µM);
    • Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=9.5 µM).
    • Fungi: Slime mould 090223 (MIC=37.5 µM), Candida albicans ATCC2002 (MIC=19 µM).

• • Hemolytic Activity

  • • LC50=300µM against human erythrocytes

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Cyclization (Cys27 and Cys33)

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bond between Cys27 and Cys33.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP01986.

DRAMP01986

• • Function

  • It shows poor hemolycity activity (LC50=300 uM).

• ·Literature 1

• • Title

  • Novel brevinins from Chinese piebald odorous frog (Huia schmackeri) skin deduced from cloned biosynthetic precursors.

• • Pubmed ID

  • 18423796

• • Reference

  • Peptides. 2008 Aug;29(8):1456-1460.

• • Author

  • Quan Z, Zhou M, Chen W, Chen T, Walker B, Shaw C.