General Information

    • DRAMP ID

    • DRAMP01993

    • Peptide Name

    • Brevinin-1Wa (Frogs, amphibians, animals)

    • Source

    • Lithobates capito (the New World frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLPVLARLAVKFLPSIVCAATKKC

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01993 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01993.

Physicochemical Information

    • Formula

    • C122H206N30O27S2

    • Absent Amino Acids

    • DEGHMNQWY

    • Common Amino Acids

    • AL

    • Mass

    • 2589.28

    • PI

    • 9.85

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +4

    • Boman Index

    • 14.94

    • Hydrophobicity

    • 1.217

    • Aliphatic Index

    • 134.17

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.43

    • Polar Residues

    • 4

DRAMP01993

DRAMP01993 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptides.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae).

    • Reference

    • Peptides. 2009 Oct;30(10):1775-1781.

    • Author

    • Conlon JM, Meetani MA, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD.