General Information

    • DRAMP ID

    • DRAMP01994

    • Peptide Name

    • Brevinin-2ISa (Frogs, amphibians, animals)

    • Source

    • Odorrana ishikawae (Endangered frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • SLLDTFKNLAVNAAKSAGVSVLNALSCKISRTC

    • Sequence Length

    • 33

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=50 µM);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 µM), S. aureus (MRSA) (MIC=100 µM), Bacillus subtilis (MIC=12.5 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01994 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01994.

Physicochemical Information

    • Formula

    • C146H252N42O46S2

    • Absent Amino Acids

    • EHMPQWY

    • Common Amino Acids

    • ALS

    • Mass

    • 3395.98

    • PI

    • 9.38

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +3

    • Boman Index

    • -25.18

    • Hydrophobicity

    • 0.512

    • Aliphatic Index

    • 112.42

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 3.91

    • Polar Residues

    • 13

DRAMP01994

DRAMP01994 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity.

Literature Information

  • ·Literature 1

    • Title

    • Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae.

    • Reference

    • Peptides. 2011 Apr;32(4):670-676.

    • Author

    • Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M.