General Information

    • DRAMP ID

    • DRAMP02002

    • Peptide Name

    • Brevinin-1P (Frogs, amphibians, animals)

    • Source

    • Rana fukienensis (Fukien gold-striped pond frog) (Rana plancyi fukienensis)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLPALIGIAAKALPSLLCKITKKC

    • Sequence Length

    • 24

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02002 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02002.

Physicochemical Information

    • Formula

    • C118H206N28O27S2

    • Absent Amino Acids

    • DEHMNQRVWY

    • Common Amino Acids

    • L

    • Mass

    • 2513.22

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +4

    • Boman Index

    • 24.91

    • Hydrophobicity

    • 1.117

    • Aliphatic Index

    • 146.67

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.43

    • Polar Residues

    • 5

DRAMP02002

DRAMP02002 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptide.(By similarity). It shows hemolytic activity against host erythrocytes.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Amphibian skin peptides and their corresponding cDNAs from single lyophilized secretion samples: identification of novel brevinins from three species of Chinese frogs.

    • Reference

    • Peptides. 2006 Jan;27(1):42-48.

    • Author

    • Chen T, Li L, Zhou M, Rao P, Walker B, Shaw C.