General Information
-
DRAMP ID
- DRAMP02003
-
Peptide Name
- Brevinin-1S (Frogs, amphibians, animals)
-
Source
- Rana schmackeri (Schmacker's frog) (Huia schmackeri)
-
Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- FFPAILRVAAKVGPAVLCAITKKC
-
Sequence Length
- 24
-
UniProt Entry
- Q2UXV9
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02003.
Physicochemical Information
-
Formula
- C118H198N30O26S2
Absent Amino Acids
- DEHMNQSWY
Common Amino Acids
- A
Mass
- 2517.18
PI
- 9.85
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 14
Net Charge
- +4
-
Boman Index
- 16.17
Hydrophobicity
- 1.179
Aliphatic Index
- 122.08
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 5.43
Polar Residues
- 4
DRAMP02003
Comments Information
Function
- Antimicrobial peptide.(By similarity)
Tissue specificity
- Expressed by the skin glands.
PTM
- Problely contains one disulfide bond 18-24.
Literature Information
- ·Literature 1
-
Title
- Amphibian skin peptides and their corresponding cDNAs from single lyophilized secretion samples: identification of novel brevinins from three species of Chinese frogs.
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Pubmed ID
- 16139929
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Reference
- Peptides. 2006 Jan;27(1):42-48.
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Author
- Chen T, Li L, Zhou M, Rao P, Walker B, Shaw C.