General Information

    • DRAMP ID

    • DRAMP02015

    • Peptide Name

    • Brevinin-2Td (Frogs, amphibians, animals)

    • Source

    • Rana temporaria (European common frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLWETIKNFGKKFTLNILHNLKCKIGGGC

    • Sequence Length

    • 29

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02015 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02015.

Physicochemical Information

    • Formula

    • C148H238N40O37S2

    • Absent Amino Acids

    • ADMPQRSVY

    • Common Amino Acids

    • GK

    • Mass

    • 3233.88

    • PI

    • 9.6

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +5

    • Boman Index

    • -14.29

    • Hydrophobicity

    • -0.059

    • Aliphatic Index

    • 94.14

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 200.89

    • Polar Residues

    • 12

DRAMP02015

DRAMP02015 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against representative Gram-negative and Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides from amphibian skin: what do they tell us?

    • Reference

    • Biopolymers. 1998;47(6):435-450.

    • Author

    • Simmaco M, Mignogna G, Barra D.