• DRAMP ID

    • DRAMP02049
    • Peptide Name

    • Brevinin-1-OR10 (Frogs, amphibians, animals)
    • Source

    • Odorrana rotodora (Chinese odorous frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • FLPAVLLVATHVLPTVFCAITRKC
    • Sequence Length

    • 24
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.4 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=27.2 µg/ml);
      • Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.8 µg/ml).
      • Yeast: Candida albicans (MIC=6.8 µg/ml).
    • Hemolytic Activity

      • [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys18 and Cys24)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys18 and Cys24.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02049 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C123H202N30O28S2
    • Absent Amino Acids

    • DEGMNQSWY
    • Common Amino Acids

    • LV
    • Mass

    • 2613.26
    • PI

    • 8.96
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 14
    • Net Charge

    • +3
    • Boman Index

    • 21.87
    • Hydrophobicity

    • 1.483
    • Aliphatic Index

    • 142.08
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 5.43
    • Polar Residues

    • 5

DRAMP02049

DRAMP02049 chydropathy plot
    • Comment

    • No comments found on DRAMP database
  • ·Literature 1
    • Title

    • Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
    • Reference

    • J Proteome Res. 2012 Jan 1;11(1):306-319.
    • Author

    • Yang X, Lee WH, Zhang Y.