General Information

    • DRAMP ID

    • DRAMP02051

    • Peptide Name

    • Lividin-1 (Brevinin-1-OR2; Frogs, amphibians, animals)

    • Source

    • Odorrana rotodora (Chinese odorous frog) (Odorrana livida)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • lividin-1

    • Sequence

    • ILPFVAGVAAEMMQHVYCAASKKC

    • Sequence Length

    • 24

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.8 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11.6 µg/ml);
      • Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.6 µg/ml).
      • Yeast: Candida albicans (MIC=5.8 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys18 and Cys24)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys18 and Cys24.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02051 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C114H183N29O30S4

    • Absent Amino Acids

    • DNRTW

    • Common Amino Acids

    • A

    • Mass

    • 2568.12

    • PI

    • 8.04

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • 10.54

    • Hydrophobicity

    • 0.808

    • Aliphatic Index

    • 89.58

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1615

    • Absorbance 280nm

    • 70.22

    • Polar Residues

    • 5

DRAMP02051

DRAMP02051 chydropathy plot

Comments Information

    • Function

    • Amphibian defensive peptide.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • Contains disulfide bond.

Literature Information

  • ·Literature 1

    • Title

    • Lividins: novel antimicrobial peptide homologs from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida. Identification by shotgun cDNA cloning and sequence analysis.

    • Reference

    • Peptides. 2006 Sep;27(9):2118-2123.

    • Author

    • Zhou M, Chen T, Walker B, Shaw C.
  • ·Literature 2

    • Title

    • Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.

    • Reference

    • J Proteome Res. 2012 Jan 1;11(1):306-319.

    • Author

    • Yang X, Lee WH, Zhang Y.