• DRAMP ID

    • DRAMP02073
    • Peptide Name

    • Brevinin-1JDa (Frogs, amphibians, animals)
    • Source

    • Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • FLPAVIRVAANVLPTVFCAISKKC
    • Sequence Length

    • 24
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.22917879]Gram-positive bacteria: Staphylococcus aureus (MIC=16 µg/ml), S. aureus (MRSA) (MIC=32 µg/ml);
      • Gram-negative bacterium: Escherichia coli (MIC=128 µg/ml);
      • Fungi: Candida albicans (MIC=128 µg/ml).
    • Hemolytic Activity

      • [Ref.22917879] It has 79.2 ± 6.8% hemolytic activity at 128 μg/mL against rabbit red blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys18 and Cys24)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys18 and Cys24.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02073 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C119H198N30O28S2
    • Absent Amino Acids

    • DEGHMQWY
    • Common Amino Acids

    • AV
    • Mass

    • 2561.19
    • PI

    • 9.5
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 14
    • Net Charge

    • +3
    • Boman Index

    • 12.97
    • Hydrophobicity

    • 1.279
    • Aliphatic Index

    • 130
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 5.43
    • Polar Residues

    • 5

DRAMP02073

DRAMP02073 chydropathy plot
    • Function

    • Has antibacterial and antifungal activity. Has hemolytic activity against rabbit erythrocytes.
    • Tissue specificity

    • Expressed by the skin glands.
    • PTM

    • contains one disulfide bonds.
  • ·Literature 1
    • Title

    • Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data.
    • Reference

    • J Proteomics. 2012 Oct 22;75(18):5807-5821.
    • Author

    • Liu J, Jiang J, Wu Z, Xie F.