General Information

    • DRAMP ID

    • DRAMP02087

    • Peptide Name

    • Brevinin-1PRb (Frogs, amphibians, animals)

    • Source

    • Rana pretiosa (North oregon spotted frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLPVLAGLTPSIVPKLVCLLTKKC

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.21295070] LC50=80μM against human erythrocytes.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys18 and Cys24)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys18 and Cys24.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02087 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02087.

Physicochemical Information

    • Formula

    • C121H209N27O28S2

    • Absent Amino Acids

    • DEHMNQRWY

    • Common Amino Acids

    • L

    • Mass

    • 2554.27

    • PI

    • 9.39

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +3

    • Boman Index

    • 29.66

    • Hydrophobicity

    • 1.267

    • Aliphatic Index

    • 154.17

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.43

    • Polar Residues

    • 6

DRAMP02087

DRAMP02087 chydropathy plot

Comments Information

    • The MIC of Ranatuerin-2PRe is >50 µM.

Literature Information

  • ·Literature 1

    • Title

    • Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis.

    • Reference

    • Dev Comp Immunol. 2011 Jun;35(6):644-649.

    • Author

    • Conlon JM, Mechkarska M, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, Hayes MP, Padgett-Flohr G.