General Information
-
DRAMP ID
- DRAMP02088
-
Peptide Name
- Brevinin-1PRc (Frogs, amphibians, animals)
-
Source
- Rana pretiosa (North oregon spotted frog)
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- FFPMLAGVAARVVPKVICLITKKC
-
Sequence Length
- 24
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Free
-
C-terminal Modification
- Cyclization (Cys18 and Cys24)
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Nonterminal Modifications and Unusual Amino Acids
- Disulfide bond between Cys18 and Cys24.
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Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02088.
Physicochemical Information
-
Formula
- C122H206N30O26S3
Absent Amino Acids
- DEHNQSWY
Common Amino Acids
- V
Mass
- 2605.34
PI
- 9.85
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 13
Net Charge
- +4
-
Boman Index
- 18.94
Hydrophobicity
- 1.283
Aliphatic Index
- 125.83
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 5.43
Polar Residues
- 4
DRAMP02088
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis.
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Pubmed ID
- 21295070
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Reference
- Dev Comp Immunol. 2011 Jun;35(6):644-649.
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Author
- Conlon JM, Mechkarska M, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, Hayes MP, Padgett-Flohr G.