General Information
-
DRAMP ID
- DRAMP02090
-
Peptide Name
- Brevinin-1Lb (Frogs, amphibians, animals)
-
Source
- Rana luteiventris (Spotted frog)
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- FLPMLAGLAASMVPKFVCLITKKC
-
Sequence Length
- 24
-
Swiss_Prot Entry
- P82826
-
Evidence code
- Protein level
Activity Information
-
Biological Activity
- Antibacterial, Anti-Gram+, Anti-Gram-, Antimicrobial
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Target Organism
-
- [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=8 μM);
- Gram-negative bacterium: Escherichia coli (MIC=16 μM).
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Hemolytic Activity
-
- Not found
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Other Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
PDB ID
- None
-
-
Physicochemical Information
-
Formula
- C120H201N27O27S4
Absent Amino Acids
- DEHNQRWY
Common Amino Acids
- L
Mass
- 2992.77
PI
- 9.67
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 12
-
Boman Index
- 29.65
Hydrophobicity
- 1.296
Aliphatic Index
- 117.92
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 5.43
Polar Residues
- 5
DRAMP02090

Comments Information
Function
- Antibacterial activity against Gram-positive and Gram-negative bacteria.
Tissue specificity
- Expressed by the skin glands.
Literature Information
- ·Literature 1
-
Title
- Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.
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Pubmed ID
- 10651828
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Reference
- Eur J Biochem. 2000 Feb;267(3):894-900.
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Author
- Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.