• DRAMP ID

    • DRAMP02090
    • Peptide Name

    • Brevinin-1Lb (Frogs, amphibians, animals)
    • Source

    • Rana luteiventris (Spotted frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • N/A
    • Sequence

    • FLPMLAGLAASMVPKFVCLITKKC
    • Sequence Length

    • 24
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=8 μM);
      • Gram-negative bacterium: Escherichia coli (MIC=16 μM).
    • Hemolytic Activity

      • N/A
    • Cytotoxicity

    • Binding Target

    • N/A
    • Linear/Cyclic/Branched

    • N-terminal modification

    • C-terminal modification

    • Other modifications

    • Stereochemistry

    • Structure

    • N/A
    • Structure Description

    • N/A
    • DRAMP02090 helical wheel diagram
    • Formula

    • C120H201N27O27S4
    • Absent Amino Acids

    • DEHNQRWY
    • Common Amino Acids

    • L
    • Mass

    • 2992.77
    • PI

    • 9.67
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 12
    • Boman Index

    • 29.65
    • Hydrophobicity

    • 129.58
    • Aliphatic Index

    • 117.92
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 5.43
    • Polar Residues

    • 5

DRAMP02090

DRAMP02090 chydropathy plot
    • Function

    • Antibacterial activity against Gram-positive and Gram-negative bacteria.
    • Tissue specificity

    • Expressed by the skin glands.
  • Literature 1
    • Reference

    • Eur J Biochem. 2000 Feb;267(3):894-900.
    • Author

    • Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.
    • Title

    • Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.